AMMPDB VER.1.1

AMMPD ver .1.1 is a manually curated, Indian medicinal plants with anti-tubercular properties.

Tuberculosis (TB) is one of humanity's deadliest and most highly contagious diseases caused by Mycobacterium tuberculosis. it's an air-borne bacterial disease. The emergence of new multi-drug resistant (MDR) and extensively drug-resistant (XDR) strains of M. tuberculosis across the planet, can be attributed to the developed resistance against both first-line and second-line drugs (Singh, 2007).

 

 

 

 

 

 

 

 

 

​

​

​

​

For centuries, medicinal plants have been a source to cure many diseases and they still continue to be a hope for several emerging strains or diseases. Since time immemorial nature has always provided humanity with remedies against diseases and nutrient products for good health through plants, which are high in medicinal values (Ashraf et al., 2020).“Plants accommodate several active compounds with important pharmacological properties, and their extracts are used for treating various diseases (Uddin et al., 2020).Plants are a rich and natural source of “alkaloids, flavonoids, phenols, chalcones, coumarins, lignans, polyketides, alkanes, alkenes, alkynes, simple aromatics, peptides, terpenes, and steroids” with therapeutic potential (Panchangam et al., 2016; Jee et al.,2016). Such properties of plants make them a crucial element for drug discovery (Ahmed et al., 2011; Katiyar et al., 2012).

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

​

​

​

The traditional healing systems with plants as the main ingredient of medicines is a source of inspiration for the discovery of several pharmaceutical drugs (Kinghorn, 2001). Certainly, plants have been used as medicines for more than 5000 years (Robinson et al., 2011) they are also used as a source of “antibiotics, antineoplastics, analgesics, and cardioprotective” (Chen et al., 2015). Natural product-derived drugs are known to be ideal antibiotics (Alvin et al., 2014). More than 80% of drugs are inspired by natural products. There is tremendous scope in discovering a drug through virtual screening from Plant-derived molecules (PDM). The extracted molecules could be further utilized to generate novel leads compounds and to screen many molecules from drug-like libraries (Barnes et al., 2012; Pathania et al., 2013).

 

 

 

 

 

 

 

 

​

 

 

 

 

 

 

​

​

​

                 

 

​

 Many interactions between drug-receptor are studied this experimentation will ultimately help to reduce the cost of developing a drug (Koehn et al.2005; Kubinyi1998; Leung et al., 2012; Ma et al.,2013) (Qamar et al. 2016). As an alternative approach, computer-aided drug designing was used and it helps to cut down the expenses by 10% (Waterbeemd, 2003).The process of conventional screening and assessing the activities, targets, and structures of phytochemicals from medicinal plants, not only is time-consuming and demands a lot of investment but also the storage, management, and retrieval of information is a laborious task. Currently, to address such issues in silico drug designing, computer-aided drug designing (CADD), computer-aided molecular modeling (CAMM), rational drug designing, computer-aided rational drug designing, and computer-aided molecular designing (CAMD) are in used. Predominantly, CAMM has secured remarkable attention for designing novel medicinal plant-based drugs.

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Such issues can be resolved using a database management system that allows the compiling of information of different attributes onto a single platform. This platform connects various interfaces according to the user requirements. The database provides the user with all the relevant information to aid their research. 

​