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WITHANIA SOMNIFERA 

Common name : Ashwagandha 
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Frequently asked questions

S.No
Phytochemical Name
Phytochemical ID
Synonym
part
2D structure
3D structure
Medicinal uses
1
(-)-ANAFERINE
CID_443143
Root
2
(22R)-14,20,27-Trihydroxy-22,26-epoxyergosta-2,5,24-triene-1,26-dione
Plant
3
(22R)-14,20-Dihydroxy-22,26-epoxyergosta-3,5,24-triene-1,26-dione
Plant
4
2,3-Didehydrosomnifericin
CID_70684083
plant
5
2,3-Dihydro-3beta-methoxy withaferin A
CID_10767792
3beta-Methoxy-2,3-dihydrowithaferin A, Quresimine A
Root
6
2,3-Dihydrowithaferin A
CID_15411208
2,3-Dihydro-Withaferin A
leaf
7
2,3-Dihydrowithanolide E
CID_131751517
Leaf
8
2,4-METHYLENE-CHOLESTEROL
CID_92113
Chalinasterol, 24-Methylenecholesterol, Ostreasterol
tissue culture
9
3-ALPHA-TIGLOYLOXYTROPANE
CID_12444363
Tropigline, Tigloidine, tigloidin
Root
10
4.beta.-Hydroxywithanolide
CID_476483
Leaf
Antimelanomic Antitumor
11
4beta-Hydroxywithanolide E
CID_73621
4beta-Hydroxywithanolide E 4-beta-Hydroxywithanolide E 4beta-hydroxywithanolide
12
4-DEOXYPHYSALOLACTONE
CID_13743195
6-Chloro-5,14,17,20-tetrahydroxy-1-oxowitha-2,24-dienolide
Shoot
13
17alpha-Hydroxywithanolide
CID_23266161
14
17-ALPHA-HYDROXYWITHANOLIDE
CID_44423097
15
24-ETHYLCHOLEST-5-EN-3-BETA-OL
CID_22012
Stigmast-5-en-3-ol
16
24-ETHYLCHOLESTA-5-(Z)-24(28)-DIEN-3-BETA-OL
CID_5281326
Isofucosterol, Fucosterol, delta5-Avenasterol, Delta 5-avenasterol, 28-Isofucosterol
17
24-Methylcholesta-5,23E-dien-3beta-ol
CID_5283652
18
24-METHYLCHOLESTA-5,24-DIEN-3BETA-OL
CID_193567
19
27-Deoxywithaferin A
CID_23266155
20
27-Hydroxywithanolide B
CID_15858981
Isofucosterol Fucosterol delta5-Avenasterol Delta 5-avenasterol 28-Isofucosterol
21
ANAFERINE
CID_440934
Anapheline
Root
22
ANAHYGRINE
CID_12306778
Root
23
BETA-SITOSTEROL
CID_222284
Sitosterol, Cupreol, Azuprostat
Tissue culture, root, leaf
Antibacterial Anticancer Antitumor Antiviral
24
CAMPESTEROL
CID_173183
Campesterin
Tissue culture
Antioxidant Hypocholesterolemic
25
CHLOROGENIC-ACID
CID_1794427
3-O-Caffeoylquinic acid, 3-(3,4-Dihydroxycinnamoyl)quinic acid, Heriguard
Leaf
Antibacterial Anticancer Antidiabetic Antimutagenic Antioxidant Antiseptic
26
CHOLINE
CID_305
Choline ion, Bilineurine
Root
Antidiabetic Antidementia
27
Cryptochlorogenic acid
CID_9798666
4-Caffeoylquinic acid, 4-O-Caffeoylquinic acid
28
CUSCOHYGRINE
CID_1201543
meso-Cuscohygrine
29
DAUCOSTEROL
CID_5742590
Sitogluside, Eleutheroside A, Alexandrin
Fruit
Antileukemic Antispasmodic Antitumor
30
DULCITOL
CID_11850
galactitol,dulcite, D-Galactitol
Antitumor
31
Hentriacontane_3D
CID_12410
32
Hentriacontane
CID_12410
n-Hentriacontane, Untriacontane, n-Hentriacontanone
33
HYDROXYPROLINE
CID_5810
L-Hydroxyproline, trans-4-Hydroxy-L-proline
Fruit
vulnerary
34
HYGRINE
CID_440933
Root
35
ISOCHLOROGENIC-ACID-C
CID_6474309
4,5-Dicaffeoylquinic acid
Leaf
36
ISOPELLETIERINE
CID_92987
Pelletierine, dl-Pelletierine, 1-(Piperidin-2-yl)propan-2-one
Root
Amblyopic Emetic Laxative Mydriatic
37
LINOLEIC-ACID_3D
CID_5280450
Plant
38
LINOLEIC-ACID
CID_5280450
Linolic acid, Telfairic acid
Plant
Antiandrogenic Anti-inflammatory cancer preventive
39
NICOTINE
CID_89594
L-Nicotine, (S)-Nicotine
Root
Analgesic Anti fumitory Epinephrininergic
40
Pseudotropine_3D
CID_449293
Root
41
Pubesenolide
CID_72999858
42
Quercetin 3-rutinoside-7-glucoside
CID_10190763
Quercetin 3-rhamnoglucoside 7-beta-glucoside
Leaf
Analgesic Antiaging Antiallergic Antibacterial Antidiabetic
43
QUERCETIN
CID_5280343
Meletin, Sophoretin, Xanthaurine
44
QUINIC-ACID
CID_6508
Leaf
Choleretic
45
Quresimine A
Plant
46
Quresimine B
Plant
47
RUTIN
CID_5280805
rutoside, Phytomelin, Quercetin 3-rutinoside
Leaf
Antiallergic Antibacterial Anticancer Antidiabetic
48
SCOPOLETIN
CID_5280460
Gelseminic acid, 7-Hydroxy-6-methoxy-2H-chromen-2-one, 6-Methylesculetin.
plant
Antibacterial Antiedema Antiseptic Antioxidant
49
SITOINDOSIDE-IX
CID_189586
Root
Immunostimulant Antistress
50
SITOINDOSIDE-X
CID_189702
4-hydroxy-1,26-dioxo-5,6:22,26-diepoxyergosta-2,24-dien-27-yl 6-o-hexadecanoylhexopyranoside
Root
immunostimulant Antistress
51
SOMNIFERANOLIDE
CID_102066415
Stem bark
52
SOMNIFERAWITHANOLIDE
CID_102066416
Stem bark
53
Somnifericin
CID_101687980
Plant
54
SOMNIFERINE
CID_14106343
Root
Hypnotic Sedative
55
SOMNIWITHANOLIDE
CID_102066417
Stem bark
56
STEARIC-ACID
CID_5281
Octadecanoic acid,Stearophanic acid, n-Octadecanoic acid
Hypocholesterolemic
57
Stigmasta-5,24(28)-dien-3-ol
CID_66739275
Stigmasta-5,24(28)-dien-3-ol
58
STIGMASTEROL
CID_5280794
Stigmasterin , beta-Stigmasterol
tissue culture, plant
Antihepatotooxic Anti-inflammatory Anti-oxidant Antiviral
59
TROPINE
CID_8424
Pseudotropine, 8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
Root
60
WITHACNISTIN
CID_54606507
Leaf
Antitumor
61
WITHAFERIN-A
CID_265237
Withaferine A
Root shoot leaf plant
Antibacterial Anticarcinomic Anti-inflammatory Antileukemic Antiseptic Antitumor Antiviral
62
Withanicandrin
CID_12444955
Leaf
63
WITHANOLIDE F
Leaf
64
WITHANOLIDE J
CID_21679022
Leaf
65
WITHANOLIDE K
Leaf
66
WITHANOLIDE L
CID_179575
Leaf
67
WITHANOLIDE M
CID_25090669
Leaf
68
WITHANOLIDE P
CID_21679034
Leaf
69
WITHANOLIDE Q
CID_101281365
Leaf
70
WITHANOLIDE R
CID_101281364
Leaf
71
WITHANOLIDE-D
CID_161671
5,6-Epoxy-4,20,22-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid delta-lactone
Leaf
Anti-inflammatory Antiseptic Antitumor
72
WITHANOLIDE-E
CID_301751
Shoot
Antitumor
73
WITHANOLIDE-G
CID_21679023
Leaf
74
WITHANOLIDE-N
CID_23266147
Leaf
75
WITHANOLIDE-O
CID_23266146
Leaf
76
WITHANOLIDE-S
CID_11049407
Leaf
77
WITHANONE
CID_21679027
Leaf shoot
78
WITHAOXYLACTONE
CID_101687981
Plant
79
Withasomniferanolide
CID_102066414
Stem bark
80
WITHASOMNIFEROL-A
CID_101710595
Root
81
WITHASOMNIFEROL-B
CID_101710596
Root
82
WITHASOMNIFEROL-C
CID_101710597
Root
83
Withasomnilide
CID_102066413
Withasomnilide
Stem bark
84
WITHASOMNINE
CID_442877
3-Phenyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole. 4H-Pyrrolo[1,2-b]pyrazole, 5,6-dihydro-3-phenyl-
Plant

The calculated IC50 values for 24hr are 350μg/ml, for 48 hr is 250 μg/ml and for 72 hr is 200μg/ml. So from this data it can be said that reduction of the cell viability is a dose as well as time dependent phenomena due to Withania somnifera crude extract treatment.

Source : Adaikkapp et al.,2012

Source for phytochemicals : Duke's and pubchem 

Disclaimer: The main motive behind the construction of this database is to compile information from the scientific literature on Indian medicinal plants to aid ongoing research efforts in the field of computational drug discovery.The curated data should be used only for research purposes and not for any self-diagnosis or any medical treatment.

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